Final part of DNA replication


DNA can only move in a 5 prime to 3 prime direction.
DNA replication is continuous on leading strand
DNA replication in bits on lagging strand

D) Okazaki fragments (little bits of DNA) need to be patched together with DNA ligase

E) DNA replication enzymes meet on side of circular chromosome opposite ori C…this equals terminus of replication.

F) Now we have 2 circular chromosomes that are partially locked, they need to be pulled apart into separate cells k
(decatenation- un-interlocking of circular chromosomes done by topoisomerase IV)
topoisomerase IV is the target of quinolone abx

DNA methylated: CH3 attached to many A's and T's in DNA (this takes longer than other steps) VERY LAST STEP


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