notes 10/14

a. Hydrostatic pressure/atmospheric pressure
i. All of the weight of the atmosphere that is pushing down on us at any second of the day
ii. We have an equal amount of pressure pushing out from the inside of us as well
iii. Bacteria we usually come into contact with best adapts to ~1 atm (pressure at sea level)
iv. There are bacteria that are adapted to much more intense pressures (bottom of ocean, etc)

Toxic Shock Syndrome – What is the relationship between having an aerobic environment or anaerobic environment in causation of TSS
• Toxic Shock Syndrome – Toxins get into your body and shock it
o Comes from leaving tampons in too long
• Regular shock:
o High fever
o Blood pressure
o Nausea, dizziness, fainting
o Generalized pain
o Can → death, organ failure
o Ex. Septic shock (kills ~100,000 people in US a year)
• Bacteria = septicemia
o Ex. Gram (-) bacteria in patient’s blood
• Antibiotic won’t help him, but would in fact make him worse
o Inflammation – general response to injury (scratching of her arm)
• Goal: get immune system cells to the sight of the injury
• Blood vessel cells shrink, making vessels in area of injury leaky
• Increase blood flow to the site of injury
• Release chemicals, like bradykynin, that signal “OW!” to the brain so hopefully we won’t do that again
o Bacterial components that → inflammation:
• LTA
• Lipid A of LPS
• Superantigens
• Whole bunch of different bacterial molecules that kick of super aggressive anti-inflammatory responses
• Ex. Toxic Shock Syndrome Toxin-1 (TSST-1)
o Produced by some staph aureus (needs oxygen to grow)

Bacterial Genetics

I. Protein!
a. Complex: made of 20 amino acids
b. Mainly what all living things are made of
c. Look like our parents because we inherited the same protein from them – egg and sperm are made mostly out of protein
d. This is why proteins should be molecule of inheritance (chemical containing instructions for how to make new organism) not DNA
II. The discovery of DNA and the Griffith experiments (draw pictures on sheet!)
a. DNA is really simple, and is not what we’re mainly made out of
i. Has 4 components
ii. A TINY minority of stuff organisms are made of

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