Microbiology Lecture Notes August 31

Koch's Postulates:
- trying to show the ling between a microbe and a particular disease or set ot syptoms
- a way to show that a specific microbe/germ causes a specific set of symptoms/diseases
- Postulates:
1) Microbe must be found in all hosts with a set of symptoms (& not be found in everyone else) this was a later addition
2) The microbe has to be gathered from sick host, grown in pure culture
3) Get the pure culture from the sick host, put the bacteria in a new host, same symptoms should occur
4) Gather the microbe from the newly sick host and it must be the same as the initial host's microbe

Exceptions to Koch's Postulates:
- tuberculosis only affects 10% of its hosts
- any microbe that cuases different effects in different hosts/people
- any microbe that can't be grown in pure culture ex) viruses
- any microbe that only lives in or causes symptoms in humans (immoral to inject humans with a microbe that can potentiall kill them)

Differences in ways Pasteur look at the world vs. Robert Koch
- Koch came up with Koch's postulates because he believed that bacteria behaved the same way and that nothing would ever change
- Pasteur believed that over time bacteria could change and cause disease one day and another day not caus a disease

Definition of microbes
- any organism so small it can't be seen with the naked eye; most can be seen with a microscope and some cannot be

- have a nuclei
- nuclei is a membrane "bag" surrounding DNA
- Majority of eukaryotes are not multi-cellular (single cellular)
- most kind of eukaryotes on earth are microscopic
- eukaryotes are all very genetically similar to each other

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